5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor
US4567186A · kind A · utility
7Cited by
2References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 14, 1985 |
| Grant date | Jan 28, 1986 |
| Priority date | — |
| Expiry date | Jan 14, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
3-Z-5-Q-1,6-naphthyridin-2(1H)-ones (I) or salts thereof, where Z is hydrogen or cyano, and Q is 2(or 3)-furanyl, 2(or 3)-thienyl, 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two methyl substituents, are useful as cardiotonic agents and corresponding compounds where Z is carboxy are useful as intermediates. Also shown as intermediates are 5-(Q-CO)-6-[2-(di-lower-alkylamino)ethenyl]-2(1H)-pyridinones (II) or salts thereof, where Q is defined as above. Processes for preparing said compounds (I and II) are shown.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.