Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US4567264A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 18, 1983 |
| Grant date | Jan 28, 1986 |
| Priority date | — |
| Expiry date | May 18, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/66
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel compounds of the general formula ##STR1## and the pharmaceutically acceptable esters and acid addition salts thereof, wherein: PA1 R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently hydrogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, N-optionally substituted alkylamido, except that when R.sup.1 is methyl, R.sup.4 is not methyl; or PA1 R.sup.2 and R.sup.3 together form --OCH.sub.2 O--; PA1 R.sup.6, R.sup.7, R.sup.8, R.sup.9 and R.sup.10 are each independently hydrogen, lower acyl, aminocarbonylmethyl, cyano, lower alkyl, lower alkoxy, trifluoromethyl, halo, lower alkylthio, lower alkyl sulfinyl, lower alkyl sulfonyl, di-lower alkyl amino; or PA1 R.sup.6 and R.sup.7 together form --CH.dbd.CH--CH.dbd.CH--; PA1 R.sup.7 and R.sup.8 together form --OCH.sub.2 O--; PA1 R.sup.11 and R.sup.12 are each independently hydrogen or lower alkyl; and PA1 W is oxygen or sulfur. These cardioselective compounds have calcium entry blockade properties and therefore are useful in therapy in the treatment of cardiovascular diseases, including arrhythmias, variant and exercise induced angina and myocardial …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.