Pyrrole containing 2-aminonitropyridine derivatives

US4567272A · kind A · utility

Assignee

• Rutgerswerke Aktiengesellschaft · DE

Inventors

• Winfried Orth
• Werner Fickert · Mannheim, DE

Key dates

• Filing date: Sep 11, 1984
• Grant date: Jan 28, 1986
• Expiry date: Sep 11, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New 2-aminonitropyridine derivatives are disclosed of the formula: ##STR1## wherein the nitro group is in the 3- or 5-position and X represents hydrogen, an alkoxy group with 1 to 3 C atoms or an unsubstituted or alkyl- or hydroxyalkyl substituted amino group, the alkyl portion of which has 1 to 3 C atoms PA1 R.sub.1 and R.sub.2 may be the same or different and represent hydrogen, divalent alkyl- with 1 to 3 C atoms, divalent cyclopropyl- or divalent alkenyl with 1 to 3 C atoms, phenylene- or divalent pyrrol and PA1 Y and Z may be the same or different and represent hydrogen, hydroxyl- or amino group of the formula II: ##STR2## wherein R.sub.3 and R.sub.4 may be the same or different and represent hydrogen, an unsubstituted alkyl or alkyl with 1 to 3 C atoms, substituted at any position by hydroxy or amino with 1 to 3 C atoms, with the proviso that whenever X represents hydrogen, then R.sub.1 and R.sub.2 cannot both be hydrogen, and R.sub.1 is not hydrogen, R.sub.2 is not divalent alkyl-, pheneylene-, divalent cycloalkyl- or divalent heterocyclic group and R.sub.3 and R.sub.4 do not both signify hydrogen. The compounds are produced by conversion of halogen-, alkoxy- or sulfonic aci…