1-Aryl 2-aminomethyl cyclopropane carboxylates (Z)
US4567288A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 1, 1984 |
| Grant date | Jan 28, 1986 |
| Priority date | — |
| Expiry date | Oct 1, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention concerns new derivatives of 1-aryl 2-aminomethyl cyclopropane carboxylates (Z), their preparation and their use as useful drugs for the treatment of various pains. The new derivatives of the present invention have the general formula I ##STR1## in which: R represents a hydrogen or halogen atom, a C.sub.1 to C.sub.4 lower alkyl group, a C.sub.1 to C.sub.4 lower alkoxy group, or a nitro, amino, sulfamoyl or hydroxy group; PA0 n represents the values 1, 2 or 3; PA0 (R).sub.n may together with the benzene ring also form the naphthyl group; PA0 R.sub.1 represents a linear or branched C.sub.1 to C.sub.5 alkyl or alkenyl group or an aryl or benzyl group; PA0 R.sub.2 and R.sub.3 represent a hydrogen atom, a linear or branched C.sub.1 to C.sub.5 alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or dialkylaminoalkyl group or an aryl, arylalkyl or cycloalkyl group; PA0 R.sub.2 and R.sub.3 possibly also forming a heterocycle of 5 or 6 members with the adjacent nitrogen atom, provided however that when R.sub.1 represents the ethyl radical and R represents a hydrogen atom, R.sub.2 and R.sub.3 cannot simultaneously represent a methyl radical.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.