Diuretic, antihypertensive and antihistaminic 7-carboxymethoxy-furo-(3,4-c)-pyridine derivatives

US4569938A · kind A · utility

Assignee

• Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS · FR

Inventor

• Andre Esanu · Paris, FR

Key dates

• Filing date: Nov 5, 1984
• Grant date: Feb 11, 1986
• Expiry date: Nov 5, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to new 1,3-dihydro-6-methyl-furo-(3,4-c)-pyridine derivatives of the general formula: ##STR1## wherein, each of A.sub.1 and A.sub.2 represents various hydrocarbon groups, to pharmaceutically acceptable salts of them, to a process for the preparation of said derivatives from the corresponding 6-hydroxy compounds, treated by ethyl bromoacetate and then hydrolyzed. The invention further provides pharmaceutical compositions wherein said derivatives are used as active ingredients. The compounds are useful as diuretics, in lowering blood pressure and as antihistaminics.