Certain 5-N-mono- or disubstituted sulfamoyl benzamides having use in treatment of emesis, impaired gastro-intestinal motility disorders and central nervous system disorders
US4569940A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 3, 1983 |
| Grant date | Feb 11, 1986 |
| Priority date | — |
| Expiry date | Jun 3, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D451/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula (I): ##STR1## wherein: one of X and Y is CO and the other is NH; PA0 R.sub.1 is C.sub.1-6 alkoxy or C.sub.1-6 alkylthio; PA0 R.sub.2 is hydrogen, trifluoromethyl, C.sub.1-6 alkylthio, C.sub.1-7 acyl, C.sub.1-7 acylamino, C.sub.1-6 alkylsulphonyl, C.sub.1-6 alkylsulphinyl, halogen, nitro or amino, aminocarbonyl or aminosulphonyl optionally N-substituted by one or two groups selected from C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl C.sub.1-4 alkyl, phenyl or phenyl C.sub.1-4 alkyl groups any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkoxy or nitro groups, or N-disubstituted by C.sub.2-5 polymethylene; PA0 R.sub.3 is amino, aminocarbonyl or aminosulphonyl N-substituted by one or two C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl C.sub.1-4 alkyl, phenyl or phenyl C.sub.1-4 alkyl groups any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkoxy or nitro groups, or N-disubstituted by C.sub.1-6 alkyl and one of the foregoing list of N-substituents or C.sub.4-5 polymethylene; PA0 R.sub.6 is C.sub.1-7 alkyl, --(CH.sub.2).sub.s R.sub.7, s being 0 to 2 and R.su…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.