Amidine compound, process for producing same and anti-complement agent comprising same
US4570006A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 24, 1984 |
| Grant date | Feb 11, 1986 |
| Priority date | — |
| Expiry date | Oct 24, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/68
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsine, anti-plasmin, anti-kallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II) EQU R.sub.1 --COOH (II) with amidinophenol compound (III) and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof. ##STR2##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.