.sup.125 I and .sup.131 I labeled phospholipids
US4571332A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 19, 1982 |
| Grant date | Feb 18, 1986 |
| Priority date | — |
| Expiry date | Sep 19, 2002 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S516/924
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
N-(3-(3-.sup.125 iodo, 4-hydroxybenzyl)propionyl)phosphatidylethanolamine[.sup.125 I-phenylpropionyl-PE], a nonexchangeable iodinated lipid of high specific radioactivity is disclosed, with a method for its synthesis as well as the synthesis of other iodinated lipids using a technique involving acylation of the amine nitrogen of a phospholipid, such as phosphatidylethanolamine, with an [.sup.125 I] or [.sup.131 I] substituted cyclic organic acid, for example, monoiodinated Bolton-Hunter reagent and purification by thin layer chromatography. The iodinated lipid may be quantitatively incorporated into vesicles for use as an accurate liposome tracer in in vitro and in vivo assays that require high levels of sensitivity unobtainable with most other lipid-labeling techniques.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.