Occlusion compound of 2-nitroxymethyl-6-chloropyridine with .beta.-cyclodextrin and process for preparation thereof
US4575548A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 26, 1984 |
| Grant date | Mar 11, 1986 |
| Priority date | — |
| Expiry date | Sep 26, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0015
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An occlusion compound of 2-nitroxymethyl-6-chloropyridine with .beta.-cyclodextrin is disclosed herein as well as a process for preparing the occlusion compound thereof. The occlusion compound of the present invention has a molar ratio of 2-nitroxymethyl-6-chloropyridine to .beta.-cyclodextrin of between about 1:1 and about 3:1. The present occlusion compound is nonvolatile, thereby overcoming the problems associated with the volatility of the 2-nitroxymethyl-6-chloropyridine for pharmacuetical preparations. The process of the present invention is carried out by reacting 2-nitroxymethyl-6-chloropyridine with .beta.-cyclodextrin either by kneading both compounds together with a small amount of a solvent or by mixing both compounds in an appropriate solvent, such as water. The occlusion compound is then precipitated, separated and further purified by conventional methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.