Mental complexes having an antineoplastic action, and medicaments containing these complexes

US4578401A · kind A · utility

Assignee

• Byk Gulden Lomberg Chemische Fabrik GmbH · DE

Inventors

• Heimo Keller · Heidelberg, DE
• Bernhard Keppler · Heidelberg, DE
• Uwe Kruger · Mühlheim an der Donau, DE
• Rudolf Linder · Konstanz, DE

Key dates

• Filing date: Apr 29, 1983
• Grant date: Mar 25, 1986
• Expiry date: Apr 29, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/003
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Metal complexes of the general formula I EQU [R.sup.1 (CH.sub.2).sub.m C(O)CR.sup.3 C(O)R.sup.2 ].sub.2 M(OR.sup.4).sub.2-n X.sub.n (I) wherein M denotes titanium, zirconium or hafnium, R.sup.1 denotes hydrogen, C.sub.1 -C.sub.8 -alkyl or phenyl, which can be monosubstituted or polysubstituted by fluorine, chlorine, bromine, nitro, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or trifluoromethyl, R.sup.2 denotes C.sub.1 -C.sub.8 -alkyl, or phenyl, which can be monosubstituted or polysubstituted by fluorine, chlorine, bromine, nitro, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or trifluoromethyl, R.sup.3 denotes hydrogen or phenyl, R.sup.4 denotes C.sub.1 -C.sub.18 -alkyl, which can be substituted by hydroxyl, C.sub.1 -C.sub.3 -alkylamino or alkali metal sulfonato groups, or denotes C.sub.5 -C.sub.8 -cycloalkyl, which can be substituted by C.sub.1 -C.sub.5 -alkyl groups, hydroxyl or alkali metal sulfonato groups, X denotes fluorine, chlorine or bromine, m denotes the number 0 or 1, but does not denote 0 if R.sup.1 denotes hydrogen, and n denotes the number 0 or 1, and, if a radical R.sup.4 contains an amino group, hydrohalides thereof, exhibit a very good cytostatic activi…