Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents
US4578403A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 11, 1984 |
| Grant date | Mar 25, 1986 |
| Priority date | — |
| Expiry date | Jun 11, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/235
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula ##STR1## wherein R may be lower alkyl, lower alkynyl aryl, or aralkyl; A may be a direct bond, lower alkylenyl, or lower alkenyl; x may be an integer from 1 to 3; Ar may be substituted or unsubstituted aromatic; R.sub.1 may be lower alkyl, lower hydroxy alkyl, lower alkenyl, lower alkynyl, or aralkyl; and pharmaceutically accepted salts thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic side effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.