Synthesis of spectinomycin analogs by an improved Grignard process
US4578485A · kind A · utility
1Cited by
7References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 8, 1984 |
| Grant date | Mar 25, 1986 |
| Priority date | — |
| Expiry date | Feb 8, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns a method for the synthesis of 6'-ethyl spectinomycin and analogs thereof, including intermediates utilized in the method. The method comprises converting an enamine by a Grignard addition to various novel dienones not hitherto known. The dienones are then hydrogenated and deblocked to obtain 6'-ethyl spectinomycin and analogs thereof. The 6'-ethyl spectinomycin and analogs thereof prepared by the invention exhibit especially good antibacterial activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.