Method for isolating and purifying antibiotics

US4581166A · kind A · utility

Assignee

• Fried Krupp · DE

Inventors

• Siegfried Peter · Erlangen, DE
• Hubert Coenen · Essen, DE
• Rainer Hagen · Leverkusen, DE

Key dates

• Filing date: May 11, 1984
• Grant date: Apr 8, 1986
• Expiry date: May 11, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D499/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is proposed for the isolation and purification of antibiotics wherein an antibiotic containing solution is extracted with an extraction agent at a temperature of from 0.degree. to 40.degree. C. and at a pressure which lies between the critical pressure and the ten-fold value of the critical pressure of the extraction agent, with the weight ratio of antibiotic containing solution to the extraction agent being 1:5 to 1:20, wherein the antibiotics are precipitated from the antibiotic containing extraction agent by reducing its density and wherein the extraction agent is recirculated. An entrainer may be added to the extraction agent. The reduction in density of the antibiotic containing extraction agent may be effected by expansion to a pressure of from 30 to 70 bar.