Inactivation of viruses containing essential lipids

US4581231A · kind A · utility

Assignee

• The United States of America, as represented by the Secretary, Health and Human Services · US

Inventors

• Robert H. Purcell · Boyds, US
• Stephen M. Feinstone · Boyds, US

Key dates

• Filing date: Aug 31, 1983
• Grant date: Apr 8, 1986
• Expiry date: Aug 31, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/24263
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of inactivating a lipid virus in a protein carrier by contacting said virus for an abbreviated period of time and ambient temperature with a halohydrocarbon solvent or treating agent, preferably chloroform, in an amount of 5% v/v to 50% v/v. Preferred lipid viruses are Hepatitis B virus (HBV) and non-A, non-B Hepatitis (NANBH).