Preparation of di- and tri-substituted xanthine compounds

US4581451A · kind A · utility

Assignee

• NESTEC S.A. · CH

Inventors

• Georges Philippossian · Lausanne, CH
• Marc Enslen · Yverdon-les-Bains, CH

Key dates

• Filing date: Jun 8, 1984
• Grant date: Apr 8, 1986
• Expiry date: Jun 8, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to xanthines corresponding to the formula ##STR1## and physiologically acceptable salts thereof, in which R.sub.1 represents C.sub.2 -C.sub.4 -alkyl, C.sub.3 -C.sub.4 -isoalkyl, CH.sub.2 -(C.sub.2 -C.sub.3 -alkenyl) or CH.sub.2 -(C.sub.3 -isoalkenyl); PA0 R.sub.3 represents C.sub.3 -C.sub.5 -alkyl, C.sub.3 -C.sub.5 -isoalkyl, CH.sub.2 -(C.sub.2 -C.sub.4 -alkenyl) or CH.sub.2 -(C.sub.3 -C.sub.4 -isoalkenyl); PA0 R.sub.8 represents H, methyl or ethyl; with the proviso that PA1 (1) when R.sub.8 represents H, R.sub.1 is allyl and PA1 (2) R.sub.1 and R.sub.3 cannot both represent butyl or allyl at the same time. The compounds show non-specific or anxiolytic sedative activity.