Process for producing a slow release composite
US4582719A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 15, 1983 |
| Grant date | Apr 15, 1986 |
| Priority date | — |
| Expiry date | Jul 15, 2003 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2063
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process is, herein disclosed, for producing a slow release composite having a physiologically active substance encapsulated therein, which comprises preparing a system wherein one or more physiologically active substances are in contact with protein from one or more protein sources, and bringing said system into direct contact with steam at temperatures between 50.degree. C. and 100.degree. C. to denature the protein and make the same hydrophobic, to thereby make a slow release composite having the physiologically active substance dispersed, fixed and encapsulated therein. And a process is also disclosed for producing a slow release composite which comprises preparing a mixture of one or more hydrophilic polymerizable monomers containing the body fluid and/or isotonic solution, protein from one or more protein sources, and one or more physiologically active substances, subjecting the mixture to direct contact with steam and irradiation with light or ionizing radiation, said treatment with steam being performed either before or simultaneously with irradiation with light or ionizing radiation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.