1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3,5-pyridinedicarboxylic acid esters useful for treating renal insufficiency

US4582840A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Bernward Garthoff · Hilden, DE
• Stanislav Kazda · Wuppertal, DE
• Andreas Knorr · Erkrath, DE
• Gunter Thomas · Arese, IT

Key dates

• Filing date: Apr 25, 1985
• Grant date: Apr 15, 1986
• Expiry date: Apr 25, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of combating a disorder of the salt balance in a patient afflicted therewith comprising administering to such patient a salt-balance restoring effective amount of a vasodilating 1,4-dihydropyridine of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is alkyl with 1 to 4 carbon atoms, and the nitro radical is in the ortho- or meta-position of the phenyl radical. The salt balance disorder may accompany the hypertensive disease or may also be aggravated by administering to such a patient a hypertension reducing agent.