Novel p-oxybenzoic acid derivatives, processes for their production and their use as drugs

US4582857A · kind A · utility

Assignee

• Klinge Pharma GmbH · DE

Inventors

• Helmut Grill
• Friedemann Reiter · Putzbrunn, DE
• Roland Loser · Feldafing, DE
• Michael Schliack · Munich, DE
• Klaus Seibel · Gräfelfing, DE

Key dates

• Filing date: Jul 20, 1984
• Grant date: Apr 15, 1986
• Expiry date: Jul 20, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D303/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

P-oxybenzoic acid derivatives of formula (1) ##STR1## wherein R.sup.1 is hydrogen, or straight or branched alkyl of one to four carbon atoms; PA1 n is 1 or 2; PA1 X is ##STR2## and R.sup.2 is --OH or --NHCH.sub.2 COOH; and non-toxic pharmaceutically acceptable salts thereof. The compounds exhibit a hypolipemic effect. They may be prepared by methods known in themselves from the corresponding ester or acid halide compounds, wherein optionally the secondary alcohol group may be oxidized to a keto group.