Patent · US Expired

Process for C-methylation of 2-methylbutyrates

US4582915A · kind A · utility

37Cited by
4References
6Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMay 23, 1985
Grant dateApr 15, 1986
Priority date—
Expiry dateMay 23, 2005

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D309/30
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Mevinolin, compactin and dihydro- and tetrahydro derivatives thereof are converted to more active HMG-CoA reductase inhibitors by C-methylation of the natural 2(S)-methylbutyryloxy side chain to form a 2,2-dimethylbutyryloxy side chain.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.