Catalytic process for preparing 3-ester-methyl cephalosporins from desacetyl-7-aminocephalosporanic acid
US4584371A · kind A · utility
4Cited by
3References
5Claims
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Key dates
| Filing date | Mar 1, 1984 |
| Grant date | Apr 22, 1986 |
| Priority date | — |
| Expiry date | Mar 1, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/90
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
3-(Activated ester)methyl-3-cephem-4-carboxylic acids are prepared by the direct reaction of a 3-hydroxymethyl-3-cephem-4-carboxylic acid with an activated-O-ester-methyl forming acylating agent in the presence of a 4-(tertiary amino)pyridine catalyst, and an acid absorbing base, in a non-polar liquid solvent at -78.degree. C. to +30.degree. C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.