Processes for preparing 6(R)-[2-[8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5 ,6,7,8,8a(S)-decahydronaphthyl-1(S)]ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydr o-2H-pyran-2-one
US4584389A · kind A · utility
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4References
6Claims
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Key dates
| Filing date | May 23, 1985 |
| Grant date | Apr 22, 1986 |
| Priority date | — |
| Expiry date | May 23, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D309/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The compound 6(R)-[2-8(S)(2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6, 7,8,8a(S)-decahydronaphthyl-1(S)ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-p yran-2-one is prepared in two steps from mevinolin and comprise reduction of the two double bonds and C-methylation of the 8(S)-(2-methylbutyryloxy) group to form the 2,2-dimethylbutyryloxy group. The two steps can be performed in either order.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.