Patent · US Expired

Methods and compositions involving polyhydroxylated polyiodo non-ionic contrast media

US4584401A · kind A · utility

5Cited by
8References
6Claims
0Family size

Assignee

Inventors

Key dates

Filing dateOct 20, 1983
Grant dateApr 22, 1986
Priority date—
Expiry dateOct 20, 2003

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY02P20/55
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Methods and compositions are provided for preparing polyhydroxylated polyiodo non-ionic contrast media. Particularly, substituted polyiodobenzamides are prepared, wherein the benzamide nitrogen is polyhydroxylated by allylic substitution on the nitrogen and oxidation of the olefinic group to provide for polyhydroxyl substitution. Amino substituents on the benzamide may be polyhydroxylated by allyl substitution or acryl substitution. All of the olefins may be oxidized simultaneously to glycols to provide for water soluble relatively non-toxic contrast media in efficient economical processes. Alternatively, the same compounds can be synthesized by alkylating N-acylbenzamide with polyacetoxyalkyl or dioxolanylalkyl halides, followed by removal of the protective groups.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.