Partially retro-inverted decapeptide as a specific renin inhibitor with high resistance to enzymatic hydrolysis
US4585586A · kind A · utility
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4Claims
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Key dates
| Filing date | May 22, 1984 |
| Grant date | Apr 29, 1986 |
| Priority date | — |
| Expiry date | May 22, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Synthesis of an analogue of the (5-14) decapeptide of equine angiotensinogen partially retro-inverted at the Phe-Phe bond, of formula: ##STR1## The retro-inverso analogue inhibits renin with high resistance to enzymatic degradation, and can be used in the treatment of renin-dependent hypertension.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.