Patent · US Expired

Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

US4585859A · kind A · utility

6Cited by

4References

8Claims

0Family size

Assignee

SRI International · US

Inventors

Carol W. Mosher · Stanford, US
George L. Tong · Cupertino, US
Edward M. Acton · Menlo Park, US

Key dates

Filing date	Apr 9, 1984
Grant date	Apr 29, 1986
Priority date	—
Expiry date	Apr 9, 2004

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A group of new daunorubicin and doxorubicin derivatives is disclosed. Included in this group are 3'-deamino-3'(3"-cyano-4"-morpholinyl doxorubicin; 3'-deamino-3'-(3"-cyano-4"-morpholinyl)-13-dihydoxorubicin; (3'-deamino-3'-(3"-cyano-4"-morpholinyl) daunorubicin; 3'-deamino-3'-(3"-cyano-4"-morpholinyl)-3-dihydrodaunorubicin; and 3'-deamino-3'-(4"-morpholinyl-5-iminodoxorubicin and derivatives thereof which have excellent activity as antitumor agents.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.