Process for the production of optically active 3-aminocarboxylic acid esters
US4585887A · kind A · utility
6Cited by
1References
11Claims
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Key dates
| Filing date | Dec 4, 1984 |
| Grant date | Apr 29, 1986 |
| Priority date | — |
| Expiry date | Dec 4, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C227/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for the production of an optically active 3-aminocarboxylic acid ester from a .beta.-keto acid ester. The .beta.-keto acid ester is converted with a chiral amine into the corresponding enamine. The enamine is converted by hydrogenation in the presence of a platinum catalyst into the corresponding N-substituted amino acid esters. Such ester mix is converted by means of HCl gas into the hydrochlorides. The latter are neutralized. Then by liberation and isolation from the neutralized products by hydrogenolysis in the presence of a palladium catalyst, the desired optically-active 3-aminocarboxylic acid ester is obtained.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.