Process for the enantioselective production of .alpha.-alkylated, acyclic .alpha.-aminocarboxylic acids
US4585892A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 27, 1984 |
| Grant date | Apr 29, 1986 |
| Priority date | — |
| Expiry date | Sep 27, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/38
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
.alpha.-Alkylated, acyclic .alpha.-aminocarboxylic acids of the formula ##STR1## where * represents a center of asymmetry, R.sup.1 is a lower alkyl, allyl, benzyl or substituted benzyl group and R.sup.2 is a lower alkyl, methoxymethyl, lower alkylmercaptoethyl, phenyl, phenyl substituted with alkyl or alkoxy, benzyl, or benzyl substituted with alkyl, alkoxy or halo are produced by an enantio-selective plural step process from the corresponding .alpha.-aminocarboxylic acid monomethyl or monoethyl amide. A particular advantage of the new process is that there can be produced from one educt-enantiomer, i.e. from an (S)- or an (R)-.alpha.-aminocarboxylic acid, selectively depending on the reaction conditions used the two enantiomeric forms of the desired .alpha.-alkyl-.alpha.-aminocarboxylic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.