Process for the preparation of barium sulfate of increased flowability and density, suitable as a radio-opaque component in radiographic contrast agents, product obtained according to this process and the radiographic contrast agent produced therefrom
US4588574A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 31, 1984 |
| Grant date | May 13, 1986 |
| Priority date | — |
| Expiry date | Jul 31, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC01P2006/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Barium sulfate suitable for the preparation of radiographic contrast agents of increased flowability and density is obtained by a high temperature treatment at 700.degree. to 1,200.degree. C. and preferably at 800.degree. to 1,000.degree. C. The barium sulfate so sintered is distinguished by a bulk density of 2.5 to 3 g/ml and its aqueous suspension, containing 200 g of barium sulfate per 100 ml, is distinguished by a viscosity of no more than 1,000 mPas. Radiographic contrast agents containing at least 200 g of sintered barium sulfate per 100 ml are outstandingly suitable for the difficult double contrast visualization of the stomach and gastric mucosa.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.