(8S)-8-fluoroerythromycin derivatives, the process for the preparation thereof and the pharmaceutical compositions containing them
US4588712A · kind A · utility
14Cited by
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10Claims
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Key dates
| Filing date | Feb 28, 1985 |
| Grant date | May 13, 1986 |
| Priority date | — |
| Expiry date | Feb 28, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
(8S)-8-fluoroerythromycin derivatives of formula ##STR1## wherein R is an optionally substituted alkyl, alkenyl or phenyl group PA1 R' is hydrogen or methyl and PA1 R" is hydrogen or hydroxy, may be prepared by fluorination of the corresponding 8,9-anhydroerythromycin 6,9-hemiketals with perchloryl fluoride in the presence of a compound ROH in strictly anhydrous conditions. The new compounds as well as their pharmaceutically acceptable esters, salts and salt-esters may be employed as the active ingredients of pharmaceutical compositions for antibacterial use suitable for oral administration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.