Selective biologically active 7-oxo-prostacyclin derivatives and pharmaceutical compositions containing same
US4588713A · kind A · utility
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9Claims
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Assignee
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Key dates
| Filing date | Jan 14, 1985 |
| Grant date | May 13, 1986 |
| Priority date | — |
| Expiry date | Jan 14, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## are disclosed wherein R.sup.1 stands for hydrogen, C.sub.1-4 straight or branched alkyl or pharmacologically acceptable cation, R.sup.2 stands for hydrogen, C.sub.1-4 alkanoyl, benzoyl, or benzoyl substituted by C.sub.1-4 alkyl or halogen, and R.sup.2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or --C.dbd.C--, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.