Inhalation pharmaceuticals

US4590206A · kind A · utility

Assignee

• Fisons plc · GB

Inventors

• Raymond B. Forrester · Rastatt, DE
• Terence D. Boardman · Palo Alto, US

Key dates

• Filing date: May 3, 1984
• Grant date: May 20, 1986
• Expiry date: May 3, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is described a finely divided inhalation drug, e.g. sodium cromoglycate, comprising a therapeutically effective proportion of individual particles capable of penetrating deep into the lung, characterized in that a bulk of the particles which is both unagglomerated and unmixed with a coarse carrier, is sufficiently free flowing to be filled into capsules on an automatic filling machine and to empty from an opened capsule in an inhalation device. A number of the individual drug particles have a spherical, collapsed spherical or ring doughnut shape. There is also described a method of making the fine particles and pharmaceutical formulations containing them.