Preparation of tri-cyclo nitriles
US4591461A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 28, 1985 |
| Grant date | May 27, 1986 |
| Priority date | — |
| Expiry date | Oct 28, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/26
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel process for the preparation of a 16-imino-17-aza-steroid of the formula ##STR1## wherein A is selected from the group consisting of hydrogen and tritium comprising reacting a compound of the formula ##STR2## wherein A has the above definition and R is an acyl of an organic carboxylic acid of 1 to 8 carbon atoms with an oximation agent to obtain a compound of the formula ##STR3## reacting the latter with an agent to form an acid chloride to obtain a compound of the formula ##STR4## reacting the latter with ammonia to obtain a compound of the formula ##STR5## reacting the latter with an alkali metal hypohalite in the presence of a base to obtain a compound of the formula ##STR6## wherein X is a halogen and reacting the latter with a base to obtain the desired compound and the novel compound of formula I wherein A is tritium and the novel intermediates of formulae III, IV, V and VI.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.