Patent · US Expired

Process for coupling biological substances by covalent bonds

US4592998A · kind A · utility

6Cited by

2References

17Claims

0Family size

Assignee

Etablissement Declare d'Utilite Publique Dit. Institut Pasteur · FR

Inventors

Stratis Avrameas · La Celle-Saint-Cloud, FR
Therese Ternynck · Paris, FR

Key dates

Filing date	Dec 15, 1983
Grant date	Jun 3, 1986
Priority date	—
Expiry date	Dec 15, 2003

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S530/866
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

This process involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. Said process making it possible for example to couple antibodies to enzymes for determining or detecting said antibodies. The process can be used for the determination of antitetanic antibodies in human serum.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.