Oligopeptide aldehydes useful as specific inhibitors of enterokinase

US4593018A · kind A · utility

Assignee

• NATIONAL RESEARCH DEVELOPMENT CORPORATION · GB

Inventors

• Brian M. Austen · London, GB
• Steven Cliffe · London, GB
• David F. Grant · Little Rock, US
• John Hermon-Taylor · London, GB

Key dates

• Filing date: Jan 7, 1985
• Grant date: Jun 3, 1986
• Expiry date: Jan 7, 2005

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the general formula: ##STR1## wherein n is an integer from 2 to 6, m is an integer from 2 to 4, p is an integer from 1 to 3, R is H, an amino protecting group conventionally used in peptide chemistry or a solid phase support, R.sub.1 is H or a carboxy protecting group conventionally used in peptide chemistry and R.sub.2 is H or alkyl or H.sub.2 N--C.dbd.NH are useful for inhibiting the activity of enterokinases.