3-aryl-7-chloro-3,4-dihydroacridine-1,9(2H,10H)-dione 1-oximes and 1-hydrazone derivatives, their salts, a process for their preparation, agents containing them and their use

US4593027A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Erhardt Winklemann · Kelkheim, DE
• Walter Durckheimer · Hattersheim, DE
• Wolfgang Raether

Key dates

• Filing date: Oct 11, 1983
• Grant date: Jun 3, 1986
• Expiry date: Oct 11, 2003

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3-Aryl-7-chloro-3,4-dihydroacridine-1,9(2H,10H)-dione 1-oximes and 1-hydrazone derivatives of the formula I ##STR1## and their physiologically tolerated acid addition and ammonium salts are described, as is a process for their preparation. The new compounds are chemotherapeutic agents and are active against protozoa, especially malaria plasmodia.