Process for the preparation of 3-trifluoromethyl-and 2,5-dimethyl-4'-hdyroxy-.alpha.-ethyl-benzhydrol, and pharmaceutical compositions containing them
US4593047A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 27, 1983 |
| Grant date | Jun 3, 1986 |
| Priority date | — |
| Expiry date | Dec 27, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C39/367
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-.alpha.-ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical characteristics nor their manufacturing processes have been disclosed in the known publications. 3-Trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-.alpha.-ethyl-benzhydrol are suitable for the treatment of acute ethanolic intoxication. Accordingly, another aspect of the invention is a pharmaceutical composition containing one of these compounds as active ingredient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.