Process for the preparation of 4-quinolinones
US4593101A · kind A · utility
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Key dates
| Filing date | Sep 20, 1984 |
| Grant date | Jun 3, 1986 |
| Priority date | — |
| Expiry date | Sep 20, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/233
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1,2,3,4-Tetrahydro-4-quinolinone of formula: ##STR1## are prepared from a 3-anilinopropionic acid of formula: ##STR2## which is treated successively with phosgene, phosgene in the presence of dimethylformamide, a Lewis acid or a strong acid, and a base. In the formula (I) and (II), R denotes a hydrogen atom, a halogen atom or an alkyl (1 to 4 carbon atoms) or alkoxy (1 to 4 carbon atoms) radical, and R.sub.1 denotes a hydrogen atom or an alkyl radical (1 to 4 carbon atoms). The compounds of formula I are useful as intermediates in the production of known drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.