Naphthalene anti-psoriatic agents

US4593120A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• Gordon H. Jones · Cupertino, US
• Michael C. Venuti · San Francisco, US
• John M. Young · Palm Harbor, US

Key dates

• Filing date: Dec 22, 1983
• Grant date: Jun 3, 1986
• Expiry date: Dec 22, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/89
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy, lower alkylthio, optionally substituted phenoxy or optionally substituted phenylthio, PA1 R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; and PA1 W is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl.