Substituted tetrapeptides
US4595677A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 23, 1983 |
| Grant date | Jun 17, 1986 |
| Priority date | — |
| Expiry date | Nov 23, 2003 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/86
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tetrapeptides of the formula I, ##STR1## in which R.sup.1 represents hydrogen or acyl, R.sup.2 represents alkyl or aralkyl, R.sup.3 represents free or functionally modified hydroxy, R.sup.4 represents free or substituted amino or free or etherified hydroxy, and -Pro-, -Phe- and -His- respectively represent the bivalent radicals of the amino acids proline, phenylalanine and histidine or the (D)-isomers thereof, salts of such compounds having salt-forming groups, and processes for their manufacture. The compounds inhibit the action of the enzyme renin and can be used as antihypertensives and for the treatment of cardiac insufficiency.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.