Method of use of 2,5-diaryl tetrahydrofurans and analogs thereof as PAF-antagonists

US4595693A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Tesfaye Biftu · Belmont, US
• Thomas W. Doebber · Scotch Plains, US
• San-Bao Hwang · Wayland, US
• Thomas R. Beattie · Scotch Plains, US
• Tsung-Ying Shen · Westfield, US
• Robert Stevenson · Grafton, GB

Key dates

• Filing date: Jun 4, 1984
• Grant date: Jun 17, 1986
• Expiry date: Jun 4, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Analogs of 2,5-Diaryl tetrahydrofurans which were substituted or unsubstituted at 3,4-positions were prepared. These compounds are found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.