Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives

US4596795A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary, Dept. of Health and Human Services · US

Inventor

• Josef Pitha · Baltimore, US

Key dates

• Filing date: Apr 25, 1984
• Grant date: Jun 24, 1986
• Expiry date: Apr 25, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B37/0015
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The administration of sex hormones, particularly testosteorne, progesterone and estradiol in the form of their complexes or inclusions with specific derivatives of cyclodextrins by the sublingual or buccal route results in effective transfer of these hormones into the systemic circulation, followed by only gradual elimination. To be effective in the above mode of administration, the derivatives of cyclodextrins must carry one or several substituents, each containing one or several hydroxy groups. Specially preferred are the following complexes: hydroxypropylbeta-cyclodextrin and poly-beta-cyclodextrin.