Pharmacologically active 3-substituted beta-carbolines useful as tranquilizers

US4596808A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Claus T. Braestrup · Copenhagen, DK
• Jogen A. Christensen · Avenue Madeleine, DK
• Mogens Engelstoft
• Guenter Neef · Berlin, DE
• Ulrich Eder · Berlin, DE
• Ralph Schmiechen · Berlin, DE
• Andreas Huth · Berlin, DE
• Dieter Rahtz · Berlin, DE
• Dieter Seidelmann · Berlin, DE
• Wolfgang Kehr
• Dieter Palenschat

Key dates

• Filing date: Dec 1, 1983
• Grant date: Jun 24, 1986
• Expiry date: Dec 1, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3-Substituted beta-carbolines of the formula ##STR1## wherein R.sup.A is H, F, Cl, Br, I, NO.sub.2, CN, CH.sub.3, CF.sub.3, SCH.sub.3, NR.sup.16 R.sup.17 or NHCOR.sup.16, PA1 wherein R.sup.16 and R.sup.17 are the same or different and each is hydrogen or alkyl, alkenyl or alkynyl each of up to 6 C-atoms, aralkyl or cycloalkyl each of up to 10 C-atoms, PA1 or wherein R.sup.16 and R.sup.17 together form a saturated or unsaturated 3-7 membered heterocyclic ring; said compounds possess valuable psychotropic properties which make them useful for example as tranquilizers.