4-(2-phenoxyethyl)-1,2,4-triazolone process intermediates
US4596884A · kind A · utility
3Cited by
2References
2Claims
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Key dates
| Filing date | Jun 3, 1985 |
| Grant date | Jun 24, 1986 |
| Priority date | — |
| Expiry date | Jun 3, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process for the preparation of 5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazolone, a useful intermediate in the synthesis of antidepressant 1,2,4-triazolones typified by 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-4-(2-phenoxethyl)-2 H-1,2,4-triazol-3(4H)-one, also known as nefazodone. The improved process is shorter and higher in yield than the former process, and the starting materials are cheap and readily available.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.