Process for the preparation of .alpha.-6-deoxy-tetracyclines
US4597904A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 17, 1984 |
| Grant date | Jul 1, 1986 |
| Priority date | — |
| Expiry date | Aug 17, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of .alpha.-6-deoxy-tetracyclines by the stereoselective heterogeneous hydrogenation of a 6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, or the simultaneous dehalogenation and stereo-selective heterogeneous hydrogenation of an 11a-halo-6-demethyl-6-deoxy-6-methylene-tetracycline or an acid addition salt thereof, in the presence of a tertiary phosphine, characterized by the use of a rhodium salt catalysts, wherein the rhodium is bonded to a polysiloxane carrier, having the following formulae: EQU Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.10 EQU Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.12 EQU Rh Cl.sub.3 [N{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.3 ].sub.15 EQU Rh Cl.sub.3 [HN{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.2 ].sub.4 EQU Rh Cl.sub.3 [HN{(CH.sub.2).sub.3 SiO.sub.3/2 }.sub.2 ].sub.8 permitting easy recovery of the rhodium, by simple filtration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.