General purpose gene synthesizer
US4598049A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 31, 1983 |
| Grant date | Jul 1, 1986 |
| Priority date | — |
| Expiry date | Aug 31, 2003 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B60/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A microprocessor controlled, general purpose gene synthesizer for programmably synthesizing selected nucleotide sequences. Depending upon a programmed chemistry, metered volumes of selected bases and reagent/solvents are sequentially metered into the bottom of a reaction cell containing solid-supported nucleotides, where desired linkages are achieved in an agitated suspension. Self-refilling syringe metering and electrically initiated, pneumatically operated valving insures economical, non-contaminated synthesis. Preprogrammed, selectable chemistries and operator programmed sequences are operatively coupled under microprocessor control to ensure a general purpose synthesizer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.