1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid, pharmacologically acceptable salts thereof and compositions containing the same for treatment of diabetes mellitus complications

US4598081A · kind A · utility

Assignees

• Nauchno-Issledovatelsky Institut Endokrinologii I Obmena Veschestv · BG
• Nauchno-Issledovatelsky Institut Farmakologii I Toksikologii · BG
• Institut Organicheckoi Khimii · BG

Inventors

• Andrei S. Efimov · Ruse, BG
• Igor M. Melnik · Ruse, BG
• Jury V. Tkachuk · Ruse, BG
• Nikolai D. Tronko · Ruse, BG
• Elena Efimova · Ruse, BG
• Irina G. Obrosova · Ruse, BG
• Vadim M. Gordienko · Ruse, BG
• Leonid A. Kaminsky · Ruse, BG
• Vasily I. Staninets · Ruse, BG
• Jury L. Zborovsky · Ruse, BG
• Nikolai A. Mokhort · Ruse, BG
• Lora M. Kirichek · Ruse, BG

Key dates

• Filing date: Aug 19, 1985
• Grant date: Jul 1, 1986
• Expiry date: Aug 19, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid having the following ructural formula ##STR1## A pharmaceutical composition for treating diabetes mellitus complications comprises an active agent and a pharmaceutical base material, wherein the active agent is a compound selected from the group consisting of 1,3-dioxo-1H-benz(de)isoquinoline-2(3H) butyric acid, and the sodium and potassium salts thereof.