Patent · US Expired

.alpha..sub.2 antagonistic 2-(4,5-dihydro-2-1H-imidazolyl)-2,3-dihydro-1H-indoles

US4598086A · kind A · utility

2Cited by
6References
2Claims
0Family size

Inventors

Key dates

Filing dateAug 10, 1984
Grant dateJul 1, 1986
Priority date—
Expiry dateAug 10, 2004

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D405/14
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Indole derivatives, in the form of racemates or optically active isomers, of the formula (I) ##STR1## in which R.sub.1 is a hydrogen atom, a linear or branched (C.sub.1-6) alkyl group, a (C.sub.3-6) cycloalkyl-(C.sub.1-4) alkyl group, a (C.sub.2-6) alkenyl group, the naphthylmethyl group, the phenethyl group or a benzyl group optionally substituted by one or more halogen atom or methyl, methoxyl or methylenedioxy group and R.sub.2 is H or a (C.sub.1-4) alkyl or allyl group, and their pharmaceutically acceptable salts; are .alpha..sub.2 -antagonists and useful for the treatment of depression, hypotension, post-operative paralytic ileum, asthma and obesity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.