V1-vasopressin antagonists
US4599324A · kind A · utility
3Cited by
3References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 21, 1984 |
| Grant date | Jul 8, 1986 |
| Priority date | — |
| Expiry date | Nov 21, 2004 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Vasopressin derivatives having V.sub.1 and oxytocin antagonist activity whose structures are characterized by a Mpa unit at position 1 and a des-Pro unit at position 7 are prepared by standard peptide synthetic methods also using an oxidative cyclization of a dimercaptan. Representative species are [1-deaminopenicillamine-2-(O-methyl)-tyrosine-7-desproline-8-arginine-9-de sglycine]vasopressin or [1-.beta.-mercaptopropionic acid-2-D-(O-ethyl)tyrosine-3-isoleucine-4-threonine-7-desproline-8-arginin e-9-desglycine]-vasopressin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.