Etianic acids as antiangiogenics

US4599331A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• Alain B. Schreiber · Sunnyvale, US
• William J. Kowalski · Palo Alto, US
• Stefan Unger · Palo Alto, US

Key dates

• Filing date: Dec 24, 1984
• Grant date: Jul 8, 1986
• Expiry date: Dec 24, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides a method for inhibiting angiogenesis in mammals. A pharmaceutically acceptable formulation containing a compound of the formula ##STR1## where X.sub.1 X.sub.2 and X.sub.3 are H, C1, or F and X.sub.3 must be H if the substituent of R.sub.1 is .alpha.OH; PA0 R.sup.1 is chosen from the group consisting of hydroxyl and hydrogen; PA0 R.sub.2 is chosen from the group of alkyloxy or thioalkyls wherein said alkyls have less than 5 carbon atoms PA0 R.sub.3 is H or an alkyl having less than 6 carbon atoms, is administered to the mammal having undesirable angiogenesis. The wavy line at C-16 refers to either .alpha. or .beta..