Antimigraine 8-[3-(4-aminocarbonyl piperazino and piperidino) propyl[xanthines
US4599338A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 16, 1985 |
| Grant date | Jul 8, 1986 |
| Priority date | — |
| Expiry date | Jan 16, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Xanthine compounds of the formula: ##STR1## in which: R.sub.1 is hydrogen or (C.sub.1 -C.sub.5) alkyl; PA0 R.sub.2 is hydrogen, (C.sub.1 -C.sub.5) alkyl optionally having a double bond, or benzyl; PA0 R.sub.3 is hydrogen or methyl; PA0 A is (CH.sub.2).sub.n, in which n is an integer from 1 to 4, optionally substituted, when n is higher than 1, by hydroxy; PA0 X is nitrogen or ##STR2## and the substituents R are each (C.sub.1 -C.sub.5) alkyl or they form together a polymethylene chain from C.sub.4 to C.sub.6, optionally containing an oxygen or a sulfur atom. These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of migraine and asthenia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.