Bisamidine derivatives of 5,10-dioxo-4,5,9,10-tetrahydro-4,9-dioxopyrenes, of 6(5H)-phenanthridones, and of phenanthridines, useful as chemotherapeutic agents

US4599409A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Balbir S. Bajwa, deceased · Yellandu, IN
• Dipak K. Chatterjee · Yellandu, IN
• Bimal N. Ganguli · Yellandu, IN
• Jurgen Reden · Yellandu, IN
• Noel De Souza · Mumbai, IN

Key dates

• Filing date: Feb 15, 1984
• Grant date: Jul 8, 1986
• Expiry date: Feb 15, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to new bisamidine derivatives of polycyclic compounds such as 5,10-dioxo-4,5,9,10-tetrahydro-4,9-dioxapyrene-6(5H)-phenanthridone and 5,10-dioxo-4,5,9,10-tetrahydro-4,9-dioxapyrenephenanthridine and to a process for their preparation. The polycyclic bisamidines according to the invention are distinguished by valuable chemotherapeutic properties, such as, for example, an action against amoebas and trichomonads.